The importance of seminal plasma in fertilization was appreciated as early as 1677 and would thus hardly seem a source for the search of antibacterial agents. The observation that seminal plasma had the ability to inhibit the growth of microorganisms in 1940 led to a systematic search for molecules possessing antimicrobial activity in addition to factors that might have a role in reproductive physiology. Extensive investigations led to the discovery in bovine seminal fluid of a 47‐residue peptide, possessing potent antimicrobial (...) activity as well as calcium transport modulatory properties in bovine sperm. We describe in this article the two, apparently unrelated, biological activities of this peptide. (shrink)

A case of a particularly severe misbehavior in a review process is described. Two reviewers simply copied and pasted their critical comments from their previous reviews without reading the reviewed manuscript. The editor readily accepted the reviewers’ opinion and rejected the manuscript. These facts give rise to some general questions about possible factors affecting the ethical behavior of reviewers and editors, as well as possible countermeasures to prevent ethical violations.

Gujarat has been identified as an enterpreneurial hub of India, primarily due to the innovative behaviour of Gujarati entrepreneurs. This has led Gujarat to become known as a model of enterpreneurial innovations. This model of enterpreneurial innovations has been developed from a study of entrepreneurs in a variety of industries from the region and several industrial clusters of enterprises in Gujarat. The study points to the transformation of many communities, particularly the Patel community, which was traditionally an agricultural community, into (...) a manufacturing class and a new emergent in Gujarat’s industrial scenario. (shrink)

In this study, we explore the future of work by examining differences in productivity when teams are composed of only humans or both humans and machine agents. Our objective was to characterize the similarities and differences between human and human–machine teams as they work to coordinate across their specialized roles. This form of research is increasingly important given that machine agents are becoming commonplace in sociotechnical systems and playing a more active role in collaborative work. One particular class of machine (...) agents, bots, is being introduced to these systems to facilitate both taskwork and teamwork. We investigated the association between bots and productivity outcomes in open source software development through an analysis of hundreds of project teams. The presence of bots in teams was associated with higher levels of productivity and higher work centralization in addition to greater amounts of observed communication. The adoption of bots in software teams may have tradeoffs, in that doing so may increase productivity, but could also increase workload. We discuss the theoretical and practical implications of these findings for advancing human–machine teaming research. (shrink)

Most clinical neurofeedback studies based on functional magnetic resonance imaging use the patient's own neural activity as feedback. The objective of this study was to create a subject-independent brain state classifier as part of a real-time fMRI neurofeedback system that can guide patients with depression in achieving a healthy brain state, and then to examine subsequent clinical changes. In a first step, a brain classifier based on a support vector machine was trained from the neural information of happy autobiographical imagery (...) and motor imagery blocks received from a healthy female participant during an MRI session. In the second step, 7 right-handed female patients with mild or moderate depressive symptoms were trained to match their own neural activity with the neural activity corresponding to the “happiness emotional brain state” of the healthy participant. The training was carried out using the rt-fMRI NF system guided by the brain-state classifier we had created. Thus, the informative voxels previously obtained in the first step, using SVM classification and Effect Mapping, were used to classify the Blood-Oxygen-Level Dependent activity of the patients and converted into real-time visual feedback during the neurofeedback training runs. Improvements in the classifier accuracy toward the end of the training were observed in all the patients [Session 4–1 Median = 6.563%; Range = 4.10–27.34; Wilcoxon Test, 2-tailed p = 0.031]. Clinical improvement also was observed in a blind standardized clinical evaluation [HDRS CE2-1 Median = 7; Range 2 to 15; Wilcoxon Test, 2-tailed p = 0.016], and in self-report assessments [BDI-II CE2-1 Median = 8; Range 1–15; Wilcoxon Test, 2-tailed p = 0.031]. In addition, the clinical improvement was still present 10 days after the intervention [BDI-II CE3-2_Median = 0; Range −1 to 2; Wilcoxon Test, 2-tailed p = 0.50/ HDRS CE3-2 Median = 0; Range −1 to 2; Wilcoxon Test, 2-tailed p = 0.625]. Although the number of participants needs to be increased and a control group included to confirm these findings, the results suggest a novel option for neural modulation and clinical alleviation in depression using noninvasive stimulation technologies. (shrink)

This article studies the eugenic theories of Marathi sexological writer and novelist Narayan Sitaram Phadke, and his attempts to domesticate the modern ideal of the adult romantic couple as a yardstick of ‘emotional democracy’ in late colonial India. Locating Phadke's work against the backdrop of the Child Marriage Restraint Act (1929) and its eugenicist concerns, I argue that he conceptualized romantic love as an emotion and a form of sociability central to the state's biopolitical schemes of ensuring modern coupledom (...) but as exceeding the state's capacity to rationally order Indian sex life. Consequently, he crafted literary supplements like the bildungsroman to circulate ‘English’ idioms of emotional and corporeal intimacy in Marathi; his novels domesticated eugenic sexology for its ‘vernacular’ audiences by advocating caste-bound romantic love as the blueprint for Indian marital coupling. As exemplified by Phadke's work, an emerging Marathi discourse of love demarcated a space for the young couple to operate as a vehicle of interpersonal openness within the constraints of the upper-caste joint family. By outlining the parameters of this Brahmanical aesthetic discourse, I show that the couple became the locus of a self-styled ‘democratic’ form of emotional attachment aimed at developing a necessary dynamism within endogamous caste-based marital arrangements without radically transforming them. The science performed through the Marathi novel in the 1920s and 1930s consequently explains the increasing prominence of romantic love as a form of developmental ‘democratic’ discourse at a time when both romantic love and democracy-in-practice were widely experienced as absent from Indian society. (shrink)